Using mechanistic models and machine learning to design single-color multiplexed Nascent Chain Tracking experiments
William Raymond, Sadaf Ghaffari, Luis U. Aguilera, Eric Ron, Tatsuya Morisaki, Zachary Fox, Michael P. May, Timothy J. Stasevich, Brian E. Munsky
This paper proposes a hybrid computational pipeline combining mechanistic models and machine learning to design single-color multiplexed Nascent Chain Tracking experiments capable of resolving multiple mRNA species.
Frontiers in Cell and Developmental Biology · May 30, 2023Peer-reviewedSystems Biology