Tatsuya Morisaki

This study uses real-time single-molecule imaging in zebrafish embryos to reveal non-canonical translation mechanisms of bmp2b mRNA.

This study identifies the mechanism of ATXN8OS CTA/CTG repeat-associated non-AUG translation through cell-free systems and live-cell imaging, revealing frameshifting and stress response involvement.

This paper presents an AI-driven method to convert antibody sequences into functional intrabodies, successfully converting 19 out of 26 sequences, including those targeting histone modifications.

The paper uses live-cell imaging to show that H3K27ac and RNAP2-Ser5ph mark distinct chromatin sites with opposing nucleosome mobility dynamics.

This paper proposes a hybrid computational pipeline combining mechanistic models and machine learning to design single-color multiplexed Nascent Chain Tracking experiments capable of resolving multiple mRNA species.

The paper develops a method to visualize and quantify Ago2's impact on mRNA translation and localization in live cells, revealing dynamics of miRNA-mediated gene silencing.

The paper uses live-cell imaging to study RNA polymerase II phosphorylation dynamics at a single gene, revealing spatial and temporal organization of phosphorylation clusters during transcription.

The paper investigates how defects in the ubiquitin-proteasome system affect mRNA translation and partitioning into stress granules during acute stress.

The paper develops a computational model to simulate single-RNA translation dynamics and evaluates experimental assays for estimating elongation kinetics.

The paper images single mRNA interactions with stress granules and P-bodies during stress, showing dynamic and stable associations influenced by mRNA length and granule size.