BioinformaticsbioRxivPreprint
Learning from and improving upon high-throughput screens for protein fitness with Generative AI - Application to BBB-crossing AAV design
Ayan Kashyap, Kumari Soniya, Anubhooti…·Prasad Chodavarapu
The paper improves protein design for BBB-crossing AAV vectors using generative AI, achieving 2x better enrichment in brain endothelial cells compared to high-throughput screen results.
DOI 10.1101/2024.12.06.627153