Author

Kruthika Avadhani

ORCID 0009-0006-5761-2982Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:deep learning· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Kumari SoniyaiD· 2 shared Antarip HalderiD· 1 shared AnubhootiiD· 1 shared Ayan Kashyap· 1 shared Chanukya NanduruiD· 1 shared Manasvi Sharma· 1 shared Prasad ChodavarapuiD· 1 shared S Kanishka· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

Kumari SoniyaORCID

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2 papers

Recent·Most cited

BiophysicsJournal of Chemical Information and ModelingPeer-reviewedDec 4, 2025

Selective Activation of GPCRs: Molecular Dynamics Shows Siponimod Binds but Fails to Activate S1PR2 Unlike S1PR1

Kumari Soniya, Kruthika Avadhani, Chanukya Nanduru, Antarip Halder

This study uses molecular dynamics to show that Siponimod binds both S1PR1 and S1PR2 but only activates S1PR1 by inducing conformational changes absent in S1PR2.

1 citation

mechanistic / dynamical modelprotein folding & dynamics

𝕏 PostBluesky

BioinformaticsbioRxivPreprintDec 6, 2024

Learning from and improving upon high-throughput screens for protein fitness with Generative AI - Application to BBB-crossing AAV design

Ayan Kashyap, Kumari Soniya, Anubhooti…·Prasad Chodavarapu

The paper improves protein design for BBB-crossing AAV vectors using generative AI, achieving 2x better enrichment in brain endothelial cells compared to high-throughput screen results.

DOI 10.1101/2024.12.06.627153

proteomicsdeep learning

𝕏 PostBluesky