Predicting the efficacy of BH3 mimetics through the profiling of multiple protein complexes in acute myeloid leukemia
Changju Chun, Ja Min Byun, Minkwon Cha, Hong-Won Lee, Byungsan Choi, Hyunwoo Kim, Saem Hong, Yunseo Lee, Ha Young Park, Youngil Koh, Tae‐Young Yoon
The paper predicts BH3 mimetic efficacy by analyzing PPI complexes in AML, identifying BCL2-BAX and BCLxL-BAK as key mediators of drug response and resistance.
bioRxiv · Jan 16, 2023 · PreprintMolecular Biology