Beyond the skin barrier: optical clearing enables non-invasive cortex-wide optical coherence angiography in mice in-vivo
Daewoon Seong, Sungbin Yun, Sangyeob Han, Sagor Biswas, Byung‐Soo Kim, Eva Remlova, Daniel Razansky, Jeehyun Kim, Zihao Ou, Mansik Jeon
This paper introduces an optical clearing method using tartrazine to enable non-invasive OCTA imaging of the mouse cortex through intact skull and scalp.
bioRxiv · Mar 5, 2026 · PreprintBioengineering