Sahak Z. Makaryan

This paper develops a mathematical framework to enhance NK cell secretion of cytolytic molecules by optimizing phosphatase inhibition and synthetic Notch signaling based on stimulation frequency.

This study uses in silico modeling to predict strategies for enhancing NK cell activation by analyzing the CD16, 2B4, and NKG2D signaling pathways.

This paper outlines an approach for parameterizing and validating systems biology models to create predictive tools that generate testable hypotheses and expand biological understanding.