Author

Jennifer A. Rohrs

University of Southern CaliforniaORCID 0000-0001-5151-2135Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:gene regulatory network inference· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Stacey D. FinleyiD· 3 shared Pin WangiD· 2 shared Allan I. LeveyiD· 1 shared Alzheimer’s Disease Neuroimaging Initiative· 1 shared Cory C. FunkiD· 1 shared Dongqing Zheng· 1 shared Elizabeth L. SiegleriD· 1 shared Leroy HoodiD· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersSystems Biology

Stacey D. FinleyORCID

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4 papers

Recent·Most cited

Multiomic Evidence for a Unified Model of Alzheimer's Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic Breakdown

Tom Paterson, Jennifer A. Rohrs, Timothy J. Hohman, Mark E. Mapstone, Peter J. Meikle, Rima F Kaddurah-Daouk, Allan I. Levey, Leroy Hood, Alzheimer’s Disease Neuroimaging Initiative, Cory C. Funk

bioRxiv · Jul 23, 2024 · PreprintNeuroscience

ERK activation in CAR T cells is amplified by CD28-mediated increase in CD3ζ phosphorylation

Jennifer A. Rohrs, Elizabeth L. Siegler, Pin Wang, Stacey D. Finley

The paper constructs a computational model of CAR T cell activation, showing CD28 enhances ERK activation by increasing CD3ζ phosphorylation kinetics.

iScience · Mar 30, 2020Peer-reviewedSystems Biology

Computational model of chimeric antigen receptors explains site-specific phosphorylation kinetics

Jennifer A. Rohrs, Dongqing Zheng, Nicholas Alexander Graham, Pin Wang, Stacey D. Finley

The paper develops a computational model to explain site-specific phosphorylation kinetics of CARs using phospho-proteomic data and mechanistic modeling.

Biophysical Journal · Aug 22, 2018Peer-reviewedSystems Biology

Constructing predictive cancer systems biology models

Jennifer A. Rohrs, Sahak Z. Makaryan, Stacey D. Finley

This paper outlines an approach for parameterizing and validating systems biology models to create predictive tools that generate testable hypotheses and expand biological understanding.

bioRxiv · Jul 4, 2018 · PreprintSystems Biology