A conserved cytoplasmic glutamic acid mediates pH-dependent gating in bacterial urea channel UreI
Anna Stoib, Sahar Shojaei, Xenia Fischer, Sandra Posch, Gianluca Parisse, Mario Frezzini, Tobias Putz, Christine Siligan, Nikolaus Goessweiner‐Mohr, Daniele Narzi, Andreas Hörner
This study identifies a conserved cytoplasmic glutamic acid in UreI channels that mediates pH-dependent gating, challenging the notion that periplasmic residues are the sole pH sensors.
bioRxiv · Dec 11, 2025 · PreprintBiophysics