Christine Siligan

This study identifies a conserved cytoplasmic glutamic acid in UreI channels that mediates pH-dependent gating, challenging the notion that periplasmic residues are the sole pH sensors.

This paper introduces a method using charged polymer-encapsulated nanodiscs and FCS to purify fluorescently labeled membrane proteins in native-like lipid environments, avoiding aggregation and enabling structural studies.

This study identifies key structural features of aquaporins through sequence, structural analysis, and simulations, revealing new insights into stability, selectivity, and mutation impact.