GenomicsbioRxivPreprint
HIRA-mediated H3.3 deposition preserves hepatocyte cell identity during liver aging
Rouven Arnold, Marcos G. Teneche, Xue Lei…·Peter D. Adams
This study shows that HIRA-mediated H3.3 deposition maintains hepatocyte identity during aging, and its loss leads to metabolic dysfunction and fibrosis, which can be partially reversed by tissue regeneration.
DOI 10.64898/2026.03.09.710643