HIRA-mediated H3.3 deposition preserves hepatocyte cell identity during liver aging
Rouven Arnold, Marcos G. Teneche, Xue Lei, Armin Gandhi, Christina Huan Shi, Jessica M. Proulx, Adarsh Rajesh, Aaron P. Havas, Shiqi Su, Annanya Sethiya, Shanshan Yin, Hiroshi Tanaka, Zong Ming Chua, Andrew Davis, Laurence Haddadin, , Peter D. Adams
This study shows that HIRA-mediated H3.3 deposition maintains hepatocyte identity during aging, and its loss leads to metabolic dysfunction and fibrosis, which can be partially reversed by tissue regeneration.
bioRxiv · Mar 11, 2026 · PreprintGenomics