TH1834-Mediated TIP60 Inhibition Protects Against Ischemia/Reperfusion Damage in Human iPSC-Derived Cardiomyocytes and Cardioids
Zhilin Qu, Sakthika Murugesan, Julia H. Ma, Genyu Wang, Nathan R. Tucker, Zhen Ma, Cynthia C. Taub, Xinrui Wang
This study shows that TH1834 inhibits TIP60, improving recovery in human iPSC-derived cardiomyocytes and cardioids after ischemia/reperfusion injury by enhancing metabolic flexibility and calcium homeostasis.
bioRxiv · Sep 18, 2026 · PreprintCell Biology