Smad1 and Smad5 differentially transduce BMP signaling during in vitro differentiation of mouse embryonic stem cells into dorsal interneurons
Salena Gallardo, Sandeep Gupta, Yahir Verdin, Cristian Rodriguez, Brian Chilin, Armo Derbarsegian, Gabriela Gajardo Del Real, Samantha J. Butler
This study investigates the distinct roles of Smad1 and Smad5 in BMP signaling during mouse ESC differentiation into dorsal interneurons, showing they have different impacts on cell fate specification.
bioRxiv · Jul 1, 2026 · PreprintDevelopmental Biology