Samantha J. Butler

This study investigates the distinct roles of Smad1 and Smad5 in BMP signaling during mouse ESC differentiation into dorsal interneurons, showing they have different impacts on cell fate specification.

The paper creates an in vivo human embryonic spinal cord atlas to study dorsal interneurons and identifies ASD-related gene enrichment in mechanosensory interneurons.

The paper identifies netrin1 as a suppressor of Bmp signaling in the dorsal spinal cord, altering interneuron patterning and Bmp activity through gain- and loss-of-function experiments in multiple models.

The paper uses pseudotime analysis of single-cell RNA-Seq data from mouse dorsal spinal interneurons to identify novel regulators and lineage relationships between interneuron populations.

This study identifies Apcdd1 as a dual inhibitor of BMP and Wnt signaling pathways in multiple organisms, revealing its role in development and disease.