DNA methylation reprogramming in marsupial embryos is restricted to the extraembryonic lineage
Allegra Angeloni, J. W. Hammond, Timothy J. Peters, Andre L. M. Reis, Leah F. Kemp, Timothy G. Amos, Hasindu Gamaarachchi, Sam Humphries, Lynda A. Wilmott, Suranjana Pal, V. Pragathi Masamsetti, Megan Weatherstone, Kenny Chi Kin Ip, Karina Pazaky, Alice Steel, , Ksenia Skvortsova
The paper examines DNA methylation dynamics in marsupial embryos, finding global demethylation in the trophectoderm but not the embryonic lineage, suggesting 5mC erasure in extraembryonic tissue is ancestral in therian mammals.
Nature Communications · Jun 15, 2026Peer-reviewedDevelopmental Biology