Single-cell Genomic Copy Number Evolution Reveals Frequent Loss of the Y chromosome in Esophageal Adenocarcinoma
Shiwei Yin, Na Zhong, Swati Agrawal, Bingru Feng, Sneha Pradhan, Nathan K. Jobalia, Maryam Vaziripour, Sampath Poreddy, Laura A. Kresty, Erin Alexis Gillaspie, Nicholas E. Dietz, Waddah B. Al‐Refaie, Kalyana C. Nandipati, Yusi Fu, Jun Xia
This study uses single-nucleus DNA and RNA sequencing to analyze LOY in EAC and find its association with tumor heterogeneity and immune evasion.
bioRxiv · Sep 14, 2025 · PreprintCancer Biology