Author

Samuel Higgins

Roche (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Approach:statistical model· 2 Approach:benchmark study· 1 Research Focus:benchmarking· 1 Assay:long-read sequencing· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Rajib SchubertiD· 2 shared William StephensoniD· 2 shared Zora D. ModrusaniD· 2 shared Alexander PopescuiD· 1 shared Ashley ByrneiD· 1 shared Barbara Morquette· 1 shared Carol X.‐Q. CheniD· 1 shared Cecilia Rocha· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBioinformatics

Rajib SchubertORCID

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2 papers

Recent·Most cited

Benchmarking long-read RNA-seq across modalities, methods, and sequencing depth in iNeurons

Gianfranco Botta, David Wissel, Samuel Higgins, Tomasz Chełmicki, Alexander Popescu, Kalina Radoynovska, Seraphin Probst, Julieta Ramírez Cuéllar, Kim Schneider, Zeynab Nayernia, Ashley Byrne, Christopher D. Nelson, Zora D. Modrusan, Stormy J. Chamberlain, William Stephenson, , Rajib Schubert

This study benchmarks long-read RNA-seq across bulk and single-cell platforms, technologies, and sequencing depths, identifying optimal methods for transcript discovery and quantification.

bioRxiv · Apr 4, 2026 · PreprintBioinformatics

Transcriptional dysregulation and impaired neuronal activity in FMR1 knock-out and Fragile X patients iPSC-derived models.

Gilles Maussion, Cecilia Rocha, Narges Abdian, Dimitri Yang, J Turk, Dulce Carrillo Valenzuela, Luisa S.B. Pimentel, Zhipeng You, Barbara Morquette, Michaël Nicouleau, Éric Deneault, Samuel Higgins, Carol X.‐Q. Chen, Wolfgang Reintsch, SK Ho, , Thomas M. Durcan

This study compares FMR1 knock-out and Fragile X patient iPSC-derived neuronal models, finding shared transcriptional and functional impairments in neuronal activity and differentiation.

International Journal of Molecular Sciences · Oct 5, 2023Peer-reviewedNeuroscience