miRNA Mimic Optimization: Chemical Structure - Activity - Targetome Relationship to Engineer Selective Anti-Tumor Immunity in T cells
Xavier Segarra-Visent, Tatyana Ryaykenen, Anastasia Kremer, Melanie Sauer, Samuel Jackson, David Cooper, Dimas Echeverria, Réka Ágnes Haraszti
This study identifies a miR-374b mimic that selectively inhibits GVHD while enhancing GvL, demonstrating the potential of chemically modified miRNA therapies to improve T-cell-based cancer treatments.
bioRxiv · Apr 16, 2025 · PreprintBioengineering