Genotype-Epigenome-Phenotype Integration Reveals the Contributions of Peripheral Immune Cells to Bipolar Disorder Pathogenesis, Phenotypic Heterogeneity, and Therapy
Lei Hou, Yue Li, Xushen Xiong, Yosuke Tanigawa, Yongjin Park, Samuel W. Lenz, Amy Grayson, Jeong‐Heon Lee, Euijung Ryu, Janet E. Olson, Joanna M. Biernacka, Mark A. Frye, Tamás Ördög, M Kellis
This study integrates genotype, epigenome, and phenotype data to show immune cells contribute to bipolar disorder pathogenesis, heterogeneity, and therapy through epigenomic and genetic mechanisms.
medRxiv · Mar 17, 2025 · PreprintGenetic & Genomic Medicine