This study integrates genotype, epigenome, and phenotype data to show immune cells contribute to bipolar disorder pathogenesis, heterogeneity, and therapy through epigenomic and genetic mechanisms.

medRxiv · Mar 17, 2025 · PreprintGenetic & Genomic Medicine

The contribution of genetic risk to the comorbidity of depression and anxiety: a multi-site electronic health records study

Brandon J. Coombes, Isotta Landi, Karmel W. Choi, Kritika Singh, Y Nina Gao, Brian Fennessy, G. Douglas Jenkins, Anthony J. Batzler, Richard S. Pendegraft, Nicolás A. Núñez, Euijung Ryu, PRIYA J. WICKRAMARATNE, Jyotishman Pathak, J. John Mann, Lea Karatheodoris Davis, , Joanna M. Biernacka

This study evaluates the association of genetic risk scores with depression and anxiety diagnoses, finding distinct genetic contributions to their comorbidity.

medRxiv · Apr 11, 2022 · PreprintGenetic & Genomic Medicine

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Raymond Kenney Walters, Renato A Polimanti, Emma C. Johnson, Jeanette N. McClintick, Mark J. Adams, Amy E. Adkins, Fazil Alıev, Silviu‐Alin Bacanu, Anthony J. Batzler, Sarah E. Bertelsen, Joanna M. Biernacka, Tim B. Bigdeli, Li‐Shiun Chen, Toni‐Kim Clarke, Yi‐Ling Chou, , Norbert Wodarz

This study conducts a trans-ancestral GWAS of alcohol dependence, identifying genetic variants and correlations with psychiatric disorders.

Nature Neuroscience · Nov 19, 2018Peer-reviewedGenetics