A novel TRPA1 gain-of-function variant associated with painful sensory neuropathy acts through a PIP2 gating mechanism
Maddalena Comini, Tanadet Pipatpolkai, Sophia Clyde, Sanda Kodele, Matilde Laurá, Andreas Themistocleous, David Bennett
This paper identifies a novel TRPA1 variant causing painful sensory neuropathy and shows it functions through a PIP2-dependent mechanism.
bioRxiv · Aug 17, 2026 · PreprintPhysiology