David Bennett

This study identifies LIF as a key pro-algesic cytokine in arthritis-related pain, showing its role in neuronal signalling and pain-like behaviours in human and mouse models.

The paper demonstrates that precision targeting of injured sensory neurons using gene therapy alleviates neuropathic pain in mice.

This paper identifies a novel TRPA1 variant causing painful sensory neuropathy and shows it functions through a PIP2-dependent mechanism.

The paper characterizes the maturation of HD10.6 human dorsal root ganglion cells over 28 days, showing transcriptional and functional changes relevant to nociception and axon injury.

This study shows that SARM1 activation causes mitochondrial dysfunction in human neurons, which can be reversed by nicotinamide or prevented by antisense oligonucleotides.

The paper identifies SLC45A4 as a pain-related gene encoding a neuronal polyamine transporter through GWAS and functional studies.

This study shows that peripheral nerve injury preferentially eliminates specific DRG neuron subpopulations, particularly non-peptidergic nociceptors, and links this loss to neurotrophic support.

This study uses in vivo calcium imaging to characterize the stimulus-response function of mouse C-low threshold mechanoreceptors to mechanical stimuli.

This paper identifies potential pain-related genes using machine learning and interaction networks, finding JAK2/STAT3, ErbB, and Rap1 pathways as promising targets.

This study investigates the role of LGI1 in pain regulation using mouse models, finding that LGI1 ablation in spinal neurons exacerbates neuropathic pain behaviors, suggesting a spinal mechanism for its role in pain sensitivity.

The paper analyzes bulk RNA-seq data from murine dorsal root ganglia neurons after nerve injury to identify sex-specific transcriptional changes across neuronal subtypes.

This study demonstrates the efficacy of a humanised chemogenetic system in silencing sensory neuron hyperexcitability and reducing pain in both mouse and human models.

The paper identifies DIRC3-IGFBP5 as a shared genetic risk locus for trigger finger and carpal tunnel syndrome, linking IGF-1 signaling to both diseases.

This study uses whole-genome sequencing in a national healthcare system to diagnose rare diseases and discover new aetiological variants, identifying 95 Mendelian associations and 4 novel non-coding disease-causing variants.

StereoMate provides an open-source image analysis framework for automated stereological analysis of immunofluorescent data from cleared tissue, revealing changes in neuronal structure following injury.

The paper identifies ADCYAP1 (PACAP) as a key molecule enhancing sensory neuron outgrowth in human nerve regeneration using carpal tunnel syndrome as a model.

This study identifies genome-wide significant genetic loci for handedness and links them to microtubule-related genes associated with brain lateralization and neurodevelopmental disorders.

Telomerecat estimates telomere length from whole-genome sequencing data without requiring prior knowledge of ploidy, showing good performance and detecting expected patterns in various data types.