Author

Sandesh Acharya

University of Calgary

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Research Focus:cell type annotation· 2 Organism:mouse· 2 Assay:scRNA-seq· 2 Organism:bacteria (other)· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Jiami GuoiD· 2 shared Qingrun ZhangiD· 2 shared Amol Dahal· 1 shared Askar Yimit· 1 shared Brandon Whitmore· 1 shared Colten Chipak· 1 shared David Elliott· 1 shared Elodie LabitiD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBioinformatics

Jiami GuoORCID

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3 papers

Recent·Most cited

Stabilized marker gene identification and functional annotation from single-cell transcriptomic data

Sandesh Acharya, Pathum Kossinna, Qingrun Zhang, Jiami Guo

The paper introduces scSCOPE, a method for identifying reproducible and functionally relevant marker genes from scRNA-seq data, showing improved consistency across datasets.

PLoS Computational Biology · Oct 17, 2025Peer-reviewedBioinformatics

The Diversified Astrocyte Developmental Programs are Modulated by Primary Ciliary Signaling

Lizheng Wang, Qianqian Guo, Sandesh Acharya, Xiao-Feng Zheng, Vanessa Huynh, Brandon Whitmore, Askar Yimit, Mehr Malhotra, Siddharth Chatterji, Nicole L. Rosin, Elodie Labit, Colten Chipak, Kelsea A. Gorzo, Jordan N. Haidey, David Elliott, , Jiami Guo

This study shows primary cilia modulate astrocyte diversity and function through Shh signaling and intracellular balance, affecting neuronal development and behavior.

bioRxiv · Mar 17, 2024 · PreprintNeuroscience

Evolution and origin of sliding clamp in bacteria, archaea and eukarya

Sandesh Acharya, Amol Dahal, Hitesh Kumar Bhattarai

The paper identifies sequence homology between bacterial beta clamps and eukaryotic PCNA, suggesting a common ancestor and using phylogenetic analysis to show vertical inheritance and horizontal gene transfer of sliding clamps.

PLoS ONE · Aug 11, 2021Peer-reviewedMolecular Biology