iPSC derived MSC secretome activates distinct neuroprotective pathways in a preclinical model of Parkinsons disease
Ana Marote, Filipa Ferreira-Antunes, Sandra Barata-Antunes, Bárbara Mendes-Pinheiro, Carina Soares‐Cunha, Ana Verónica Domingues, Stephanie Oliveira, Sandra Isabel Anjo, Daniela Monteiro, Patrícia Patrício, Bruno J. Manadas, Andreia Castro, Luísa Pinto, Belém Sampaio‐Marques, António José Salgado
The paper compares the neuroprotective effects of bone marrow MSCs and iPSC-derived MSCs secretomes in a Parkinson's disease model, finding that iMSCs secretome better preserves dopaminergic neurons and activates broader protective pathways.
bioRxiv · Nov 7, 2025 · PreprintNeuroscience