Lysine-rich regions located in the C-terminal domain of DNA Topoisomerase 2-alpha act as polyphosphoinositide interaction sites and nucleolar localisation signals
Vandana V. Ardawatia, Rhîan G. Jacobsen, Diana Cornelia Turcu, Sandra Ninzima, Niclas P. Decker, Amanda J. Edson, Aurélia E. Lewis
The paper identifies lysine-rich regions in TOP2A's C-terminal domain as PPIn interaction sites and nucleolar localisation signals, showing their role in nuclear PPIn dynamics.
bioRxiv · Jan 29, 2025 · PreprintMolecular Biology