Attenuation of endothelial glycocalyx shedding and endocan modulation by Sulodexide in murine models of anaphylaxis.
Lucia Palacio-García, Sergio Fernández‐Bravo, Irene De Maria-Camacho, Irene San Sebastián-Jaraba, María José Fernández-Gómez, Óscar López-Pérez, Sandra Sanz-Andrea, Carlos Pastor‐Vargas, Emilio Nuñez‐Borque, José Julio Laguna, Marcela Valverde‐Monge, Luis Miguel Blanco‐Colio, Vanesa Esteban, Nerea Méndez‐Barbero
This study investigates the role of endothelial glycocalyx shedding in murine anaphylaxis and shows that Sulodexide reduces severity and improves survival by preserving the glycocalyx and modulating endocan.
bioRxiv · Oct 16, 2025 · PreprintImmunology