Rotating a petavoxel reconstruction exposes the viewing-angle bias inherent to Golgi-Cox and confocal dendritic-spine classification
Elı́as Manjarrez, Sandra T. Hernandez, Miguel Angel Zamora-Ursulo, Amira Flores
The paper shows that dendritic spine shape classification varies with viewing angle, challenging traditional 2D methods like Golgi-Cox and confocal microscopy.
bioRxiv · Jun 19, 2026 · PreprintNeuroscience