Evidence for the coupling of substrate recognition with transporter opening in MOP-family flippases
Lok To Sham, Sanduo Zheng, Andrew C. Kruse, Thomas G. Bernhardt
The paper investigates how MOP-family flippases recognize and transport lipid-linked oligosaccharides, finding that substrate binding destabilizes the inward-open conformation to promote translocation.
bioRxiv · Feb 6, 2018 · PreprintMicrobiology