Sanduo Zheng

Allosteric modulation of dimeric GPR3 by ligands in the dimerization interface

This study determines cryo-EM structures of GPR3 in active and inactive states, revealing dimerization mechanisms and identifying a negative allosteric modulator targeting the dimerization interface.

SARM1 Activation Promotes Axonal Degeneration Via a Two-Step Liquid-to-Solid Phase Transition

This study reveals a two-step liquid-to-solid phase transition mechanism by which SARM1 activation leads to axonal degeneration, with implications for therapeutic development.

Structural insights into G protein activation by D1 dopamine receptor

The paper presents cryo-EM structures of D1 dopamine receptor-Gs complexes in different nucleotide states, revealing conformational changes and a sequence motif that determines G protein selectivity.

Structural insights into the galanin receptors signaling

The paper reports cryo-EM structures of GALR1-Go and GALR2-Gq complexes with galanin and spexin, revealing structural determinants for G protein selectivity and the role of zinc as a negative allosteric regulator.