Restoration of circulating 2-arachidonoylglycerol levels attenuates cocaine self-administration through endocannabinoid-dopamine interactions in common marmosets
Chul Kyu Lee, Heejong Eom, Taeyun Yoo, Sun Mi Gu, Jae-Jun Lee, Hyeokjun Kwon, Sang-Beom Na, Eunbin Kim, Tae Hwan Kim, Chun‐Woong Park, Bang-Yeon Hwang, Seong Shoon Yoon, Dohyun Lee, Jaesuk Yun
This study shows that restoring 2-AG levels reduces cocaine self-administration in marmosets by modulating dopamine and GPR55/DAT interactions.
bioRxiv · Sep 4, 2026 · PreprintPharmacology & Toxicology