Linker stretching optimizes bonding entropy in sticker-spacer condensates
Sk Ashif Akram, Junlang Liu, Aniruddha Chattaraj, Sanjeev Gautam, Buddhapriya Chakrabarti, Eugene Shakhnovich, Jeremy D. Schmit
The paper develops a mean-field theory to show that linker stretching optimizes bonding entropy in sticker-spacer condensates by canceling length-dependent terms, supporting decoupling approximations.
bioRxiv · Oct 11, 2026 · PreprintBiophysics