Aniruddha Chattaraj

The paper identifies synergistic drug pairs in branched metabolic networks by analyzing topological complementarity in the E. coli folate pathway.

The paper develops a mean-field theory to show that linker stretching optimizes bonding entropy in sticker-spacer condensates by canceling length-dependent terms, supporting decoupling approximations.

CASPULE simulates and analyzes sticker-spacer polymer condensates using a novel force field and provides statistical tools to characterize cluster size distributions.

The paper derives a solubility product model for biomolecular phase boundaries, showing it accounts for variable stoichiometry and soluble oligomers, revealing curvature and re-entrant behavior in phase boundaries.

The paper demonstrates that multiple biomolecular condensates can optimize cell signaling output by maximizing actin polymerization through an optimal number of condensates.

The paper measures the solubility product in a model condensate to predict phase separation, finding that small oligomers and homotypic interactions influence the threshold.

The paper introduces a Python package for simulating and analyzing multivalent biomolecular clusters using stochastic simulations.