Jeremy D. Schmit

The paper develops a mean-field theory to show that linker stretching optimizes bonding entropy in sticker-spacer condensates by canceling length-dependent terms, supporting decoupling approximations.

This study uses UV-induced thymine dimerization to control mechanochemistry and fusion dynamics of biomolecular condensates, revealing how photochemical reactions influence their behavior.

This study shows that structural defects in amyloid-β fibrils are key sites for secondary nucleation, suggesting new strategies for drug design to inhibit amyloid disorders.

The paper derives a solubility product model for biomolecular phase boundaries, showing it accounts for variable stoichiometry and soluble oligomers, revealing curvature and re-entrant behavior in phase boundaries.

The paper shows how molecular interactions can encode multiphase architecture in cellular condensates and demonstrates a framework for engineering such structures with multiple coexisting phases.

This study shows that phosphorylation enables distinct nucleation mechanisms for NSP5 condensate formation in rotaviruses, depending on strain-specific LLPS propensity.

The paper quantifies microenvironment structure within cellular condensates using partitioning measurements, revealing spatial inhomogeneity and its role in macromolecular transport.