IKKβ as a putative non-covalent and quinone-mediated covalent target of 4-methylcatechol in RANKL/NF-κB signaling: a combined computational and experimental analysis
Chengxu Xie, Lifang Zhang, Xinyi Bao, Xiaohan Li, Yili Ding, Mojtaba Tabandeh, Farwa Basit, Heriberto Vélëz, Santosh Kumar, Vishwa Deepak
This study investigates how 4-methylcatechol affects RANKL-induced osteoclastogenesis by targeting IKKβ through non-covalent and covalent mechanisms.
bioRxiv · Aug 4, 2026 · PreprintPharmacology & Toxicology