Viral Protease Nsp5 Hijacks La Autoantigen to Orchestrate the Translation to Replication Transition in SARS-CoV-2
Risabh Sahu, Harsha Raheja, Gagan Gaurav S N, Santu Paul, Sabari Shree V, Pritam Kumar Ghosh, Raju S Rajmani, Saumitra Das
This paper shows that SARS-CoV-2's Nsp5 protease cleaves La protein to switch viral RNA from translation to replication.
bioRxiv · Aug 5, 2026 · PreprintMicrobiology