Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma
James Purzner, Alexander S. Brown, Teresa Purzner, Lauren Ellis, Sara Broski, Ulrike M. Litzenburger, Kaytlin Andrews, Aryaman Sharma, Xin Wang, Michael D. Taylor, Yoon‐Jae Cho, Margaret T. Fuller, Matthew P. Scott
This study shows Ezh2 suppresses differentiation gene activation in cerebellar granule neurons and medulloblastoma cells, and its inhibition combined with cell cycle exit promotes differentiation.
bioRxiv · Nov 21, 2024 · PreprintCancer Biology