Author

Alexander S. Brown

Stanford Medicine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Approach:experimental assay· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1

Frequent Co-Authors

Aryaman SharmaiD· 2 shared James PurzneriD· 2 shared Kaytlin AndrewsiD· 2 shared Lauren EllisiD· 2 shared Margaret T. FulleriD· 2 shared Matthew P. ScottiD· 2 shared Teresa PurzneriD· 2 shared Alex M RohacekiD· 1 shared

Activity by Year

2018-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

Aryaman SharmaORCID

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Author profile →

4 papers

Recent·Most cited

Dexamethasone-Induced p57-Mediated Quiescence Drives Chemotherapy Resistance in Sonic Hedgehog Medulloblastoma

Aryaman Sharma, Lauren Ellis, Kaytlin Andrews, Alexander S. Brown, Margaret T. Fuller, Matthew P. Scott, Teresa Purzner, James Purzner

bioRxiv · Apr 27, 2025 · PreprintCancer Biology

Ezh2 Delays Activation of Differentiation Genes During Normal Cerebellar Granule Neuron Development and in Medulloblastoma

James Purzner, Alexander S. Brown, Teresa Purzner, Lauren Ellis, Sara Broski, Ulrike M. Litzenburger, Kaytlin Andrews, Aryaman Sharma, Xin Wang, Michael D. Taylor, Yoon‐Jae Cho, Margaret T. Fuller, Matthew P. Scott

This study shows Ezh2 suppresses differentiation gene activation in cerebellar granule neurons and medulloblastoma cells, and its inhibition combined with cell cycle exit promotes differentiation.

bioRxiv · Nov 21, 2024 · PreprintCancer Biology

Genomic architecture of Shh dependent cochlear morphogenesis

Victor Muthu, Alex M Rohacek, Yao Yao, Staci M. Rakowiecki, Alexander S. Brown, Ying-Tao Zhao, James Meyers, Kyoung‐Jae Won, Shweta Ramdas, Christopher D. Brown, Kevin A. Peterson, Douglas J. Epstein

The paper identifies Shh responsive genes and regulatory sequences involved in cochlear morphogenesis using genomic approaches.

Development · Jan 1, 2019Peer-reviewedDevelopmental Biology

MTSS1/Src family kinase Dysregulation Underlies Multiple Inherited Ataxias

Alexander S. Brown, Pratap Meera, Banu Altindag, Ravi Chopra, Emma Perkins, Sharan Paul, Daniel R. Scoles, Eric Tarapore, Jessica Magri, Haoran Huang, M. T. Jackson, Vikram G. Shakkottai, Thomas S. Otis, Stefan M. Pulst, Scott X. Atwood, Anthony E. Oro

This study identifies MTSS1/Src family kinase dysregulation as a common mechanism in multiple inherited ataxias and shows SFK inhibitors can delay disease progression in mouse models.

Proceedings of the National Academy of Sciences · Dec 7, 2018Peer-reviewedNeuroscience