Viral delivery of tissue nonspecific alkaline phosphatase diminishes craniosynostosis in one of two FGFR2C342Y/+ mouse models of Crouzon syndrome.
Hwa Kyung Nam, Iva Veselá, Sara Dean Schutte, Nan E. Hatch
This study shows that delivering recombinant TNAP via lentivirus reduces craniosynostosis severity in a neonatal mouse model but not in a postnatal model, with effects dependent on genetic background.
PLoS ONE · May 29, 2020Peer-reviewedDevelopmental Biology