Nan E. Hatch

Viral delivery of tissue nonspecific alkaline phosphatase diminishes craniosynostosis in one of two FGFR2C342Y/+ mouse models of Crouzon syndrome.

This study shows that delivering recombinant TNAP via lentivirus reduces craniosynostosis severity in a neonatal mouse model but not in a postnatal model, with effects dependent on genetic background.

Modifiers and Mediators of Craniosynostosis Severity Revealed by Differential Gene Expression

The paper compares gene expression in two mouse models of craniosynostosis to identify genetic modifiers affecting disease severity.