Real-Time Selective Sequencing with RUBRIC: Read Until with Basecall and Reference-Informed Criteria
Harrison S. Edwards, Raga Krishnakumar, Anupama Sinha, Sara W. Bird, Kamlesh D. Patel, Michael S. Bartsch
The paper introduces RUBRIC, a real-time selective sequencing method for nanopore sequencing that uses on-line basecalling to align against references and make sequence/reject decisions, showing improved performance on mixed samples.
Scientific Reports · Aug 7, 2019Peer-reviewedBioinformatics