Regulation of Toxic RNA Foci and Repeat Expansion DMPK Transcripts: Role of MBNL Proteins and RNA Decay Pathways
Xiaomeng Xing, Róbert Márkus, Tushar Ghosh, Sarah Buxton, Daniel J. Nieves, Marzena Wojciechowska, J. David Brook
This study investigates how MBNL proteins and RNA decay pathways regulate mutant DMPK mRNA in DM1, showing that their absence reduces RNA foci and promotes mRNA degradation.
bioRxiv · Sep 28, 2023 · PreprintGenetics