In search of nonlipogenic ABCA1 inducers (NLAI): precision coregulator TR-FRET identifies diverse signatures for LXR ligands
Megan S. Laham, Martha S Ackerman-Berrier, Fahmida Alam, Sarah Turner, Ganga Reddy Velma, Christopher Penton, Soumya Reddy Musku, Manan Rana, Senthilkumar Thulasingam, Annadurai Anandhan, Maha Ibrahim Sulaiman, Nina Ma, Gregory R. J. Thatcher
The paper identifies diverse LXR ligand signatures using TR-FRET assays to guide the design of nonlipogenic ABCA1 inducers.
bioRxiv · Sep 12, 2025 · PreprintPharmacology & Toxicology