Author

Annadurai Anandhan

University of ArizonaORCID 0000-0002-2140-1183Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Aubin MoutaliD· 1 shared Christopher Penton· 1 shared D.D. Zhang· 1 shared Fahmida AlamiD· 1 shared Ganga Reddy Velma· 1 shared Gregory R. J. ThatcheriD· 1 shared Jie YuiD· 1 shared Lalitha MadhavaniD· 1 shared

Activity by Year

2019-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperNeuroscience

Aubin MoutalORCID

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3 papers

Recent·Most cited

In search of nonlipogenic ABCA1 inducers (NLAI): precision coregulator TR-FRET identifies diverse signatures for LXR ligands

Megan S. Laham, Martha S Ackerman-Berrier, Fahmida Alam, Sarah Turner, Ganga Reddy Velma, Christopher Penton, Soumya Reddy Musku, Manan Rana, Senthilkumar Thulasingam, Annadurai Anandhan, Maha Ibrahim Sulaiman, Nina Ma, Gregory R. J. Thatcher

The paper identifies diverse LXR ligand signatures using TR-FRET assays to guide the design of nonlipogenic ABCA1 inducers.

bioRxiv · Sep 12, 2025 · PreprintPharmacology & Toxicology

α-synuclein over expression, NRF2 suppression, and enhanced ferroptosis creates a vicious cycle of neuronal loss in Parkinson's disease

Annadurai Anandhan, W Chen, Lan Ngoc-Nguyen, Lalitha Madhavan, Matthew B. Dodson, D.D. Zhang

In Parkinson's disease models, alpha-synuclein overexpression sensitizes neurons to ferroptosis, potentially by suppressing NRF2 protein, while Nrf2 loss increases ferroptosis markers, alpha-synuclein pathology, and behavioral deficits.

bioRxiv · Jul 22, 2022 · PreprintNeuroscience

TAF1-gene editing impairs Purkinje cell morphology and function

Udaiyappan Janakiraman, Jie Yu, Aubin Moutal, Shelby N. Batchelor, Annadurai Anandhan, Rajesh Khanna, Mark A. Nelson

This paper develops a novel rat model for TAF1 ID syndrome using CRISPR-Cas9 and lentiviral transduction, showing Purkinje cell hypoplasia and behavioral deficits.

bioRxiv · Feb 9, 2019 · PreprintNeuroscience