Limited value of Nanopore adaptive sampling in a long-read metagenomic profiling workflow of clinical sputum samples
Weizhen Xu, Janetta Top, Mattheus C. Viveen, Andrii Slyzkyi, Noud Hermans, Sarah van Erp, Dafna Eiloz, Richard M. Anthony, Kristin Kremer, Anita C. Schürch
This study evaluates the effectiveness of Oxford Nanopore adaptive sampling in metagenomic profiling of clinical sputum samples, finding limited enrichment and significant pore loss issues.
BMC Medical Genomics · Dec 1, 2025Peer-reviewedMicrobiology