Transforming avian to mammalian modes of digit patterning
Sarah Wiggins, Sofia Sedas Perez, Marysia Placzek, Rory L. Cooper, Matthew Towers
The paper shows that the Shh-p27Kip1 pathway in avian ZPAs controls digit number and identity, and demonstrates that manipulating this pathway can transform chick legs into mammalian-like pentadactyl limbs.
bioRxiv · Jul 1, 2026 · PreprintDevelopmental Biology