Sofia Sedas Perez

The paper shows that the Shh-p27Kip1 pathway in avian ZPAs controls digit number and identity, and demonstrates that manipulating this pathway can transform chick legs into mammalian-like pentadactyl limbs.

This study generates human hindlimb/genital tubercle progenitors from pluripotent stem cells using WNT-FGF-BMP signaling and shows their developmental potency through xenografting.

The paper identifies Fgf signalling's role in triggering a mesodermal timer that controls limb patterning duration using an ex vivo chick wing explant system.