Macrophage depletion restores the DRG microenvironment and prevents axon degeneration in bortezomib-induced neuropathy
Michael B Thomsen, Abhishek Gajendra Singh, Christina N. Thebeau, Vivian D. Gao, Nicholas F. Schulze, Oshri Avraham, Sarah X. Yang, Shriya Koneru, Sami S. Geier, Shannon M. Landon, Aidan Pelea, Valeria Cavalli, Stefanie Geisler
The paper shows that macrophage depletion prevents axon degeneration in bortezomib-induced neuropathy by restoring the DRG microenvironment and reducing inflammation and ECM dysregulation.
bioRxiv · Jan 22, 2025 · PreprintNeuroscience