Valeria Cavalli

This study identifies Fibulin-2 released by satellite glial cells as a regulator of sensory neuron excitability, with implications for pain management.

The paper constructs a single-cell atlas of peripheral glia, identifies progenitor-like states, and shows their role in injury response and development.

The paper constructs a single-cell atlas of dorsal root ganglion remodeling after nerve injury and compares interventions to identify glial and immune programs associated with pain and regeneration.

This paper creates a multi-omic atlas of human autonomic and sensory ganglia, identifying cell-type-specific features and disease associations in peripheral neuropathies.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

This study creates a single-nucleus multi-omic atlas of human dorsal root ganglia, identifying novel regulatory mechanisms and therapeutic targets for pain.

The paper shows that macrophage depletion prevents axon degeneration in bortezomib-induced neuropathy by restoring the DRG microenvironment and reducing inflammation and ECM dysregulation.

Inhibition of endothelin B receptor improves axon regeneration and reverses age-related decline in sensory neurons.

The paper identifies mossy cell hypo-excitability in FXS due to increased Kv7 function and shows that circuit-based Kv7 inhibition normalizes dentate output.

The paper characterizes the transcriptional profile of Satellite Glial Cells (SGC) in mouse, rat, and human at the single-cell level, finding conserved key features across species.

This study compares the DRG microenvironment's response to peripheral and central axon injuries using single-cell profiling, identifying PPAR pathway activation in satellite glial cells as critical for peripheral regeneration.

This study identifies FKBPL and FKBP8 as proteins that regulate DLK stability and degradation, affecting neuronal responses to axon injury but not regeneration.

The paper identifies chromatin accessible sites and transcription factors in RGCs that correlate with axon growth capacity and shows CREB overexpression promotes axon regeneration.

This study shows that spinal cord injury (SCI) in dorsal column sensory neurons leads to downregulation of lipid metabolism genes, unlike sciatic nerve injury, which may hinder axon regeneration.

This study identifies fatty acid synthesis in satellite glial cells as a mechanism promoting axon regeneration after nerve injury.