Enrichment of somatic mutations in schizophrenia brain targets prenatally active transcription factor bindings sites
Eduardo A. Maury, Attila Jones, Vladimir B. Seplyarskiy, Chaggai Rosenbluh, Taejeong Bae, Yifan Wang, Alexej S. Abyzov, Sattar Khoshkoo, Yasmine Chahine, Brain Somatic Mosaicism Network, Peter J. Park, Schahram Akbarian, Eunjung Alice Lee, Shamil R. Sunyaev, Christopher A. Walsh, Andrew J. Chess
The paper identifies prenatal mutational processes in schizophrenia brains linked to transcription factor binding sites and proposes a new term 'skiagenesis' for these mutations.
bioRxiv · Feb 23, 2022 · PreprintGenomics